![]() A scratch wound healing migration assay was performed to determine the effects of bevacizumab and/or CsA. ![]() Rates of cell migration from explant-cultured pterygia tissues and scratch-wounded confluent pterygium fibroblasts were examined in the presence of MMP-3 or MMP-13 inhibitors, as well as bevacizumab and/or CsA. Immunofluorescence staining was used to examine expression of both MMPs in fibroblasts migrating out from explanted pterygium tissues. Expression levels of MMP-3 and MMP-13 were examined after bevacizumab administration. Fibroblasts were obtained from 20 pterygia and 6 normal conjunctival specimens. We examined the connection between matrix metalloproteinase (MMP) expression/activity and pterygium fibroblast migration, and how these were affected by bevacizumab and/or cyclosporine A (CsA).
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